Melanie Georgiou
Postdoctoral Research Associate Department of Biochemical Engineering, UCL [email protected] As a UCL Biochemical Engineering graduate, I have a central interest in translating basic science to the clinic, specifically for the treatment of nervous system injuries. My PhD, obtained in 2013, focused on the development of a peripheral nerve repair device, under the guidance of Dr James Phillips at the Open University. The research has yielded publications, a patent and 1st prize oral presentation at the 3rd TERMIS world congress in Vienna. Since 2013, I have been a post-doctoral researcher in Dr Ivan Wall’s lab, UCL, continuing to investigate candidate solutions to nervous system injury. Project: Commercial scale manufacture of adult allogeneic cell therapy for regenerative medicine
Project Ref. BB/K011154/1 The current project is aimed at generating stable allogeneic cell lines from olfactory ensheathing cells for the treatment of spinal cord injury. The project aims to develop a new cell line with pioneering British regenerative medicine company ReNeuron. This project aims to address a key bioprocess challenge, which is to create new platform technologies that have generic potential for large-scale expansion of therapeutic cell products to fulfil the needs of the industry and facilitate safe administration of novel treatments. Publications and Presentations2015 Engineered neural tissue with aligned, differentiated adipose-derived stem cells promotes peripheral nerve regeneration across a critical sized defect in rat sciatic nerve.
Georgiou, Melanie; Golding, Jon P.; Loughlin, Alison J.; Kingham, Paul J. and Phillips, James B Biomaterials, 37 pp. 242–251. 2014Advances in tissue engineering and regenerative medicine to treat nervous system trauma
Georgiou, Melanie; Phillips, James B.; Wall, Ivan In: Tissue Engineering and Regenerative Medicine International Society - AP Meeting, 24 - 27 September 2014, Daegu, South Korea. IMPROVING YIELD AND EXPANSION OF PRIMARY OLFACTORY ENSHEATHING CELLS TO GENERATE STABLE CELL LINES FOR SPINAL CORD INJURY Georgiou, M., Choi, D., Li, D., Mason, C., Raisman, G., Jat, P., & Wall, I WOUND REPAIR AND REGENERATION, 22 (5), A81 Human dental pulp stem cells can differentiate into Schwann cells and promote and guide neurite outgrowth in an aligned tissue-engineered collagen construct in vitro. Martens, Wendy; Sanen, Kathleen; Georgiou, Melanie; Struys, Tom; Bronckaers, Annelies; Ameloot, Marcel; Phillips, James and Lambrichts, Ivo FASEB Journal, 28(4), pp. 1634–1643. 2013A 3D in vitro model reveals differences in the astrocyte response elicited by potential stem cell therapies for CNS injury.
East, Emma; Johns, Noemie; Georgiou, Melanie; Golding, Jon; Loughlin, Jane; Kingham, Paul and Phillips, James Regenerative Medicine, 8(6), pp. 739–746. Aligned Schwann cells derived from human dental pulp stem cells direct neurite growth in a tissue engineered collagen construct. Sanen, Kathleen; Martens, Wendy; Georgiou, Melanie; Phillips, James; Lambrichts, Ivo and Ameloot, Marcel In: XI European Meeting on Glial Cells in Health and Disease, 3-6 July 2013, Berlin, Germany. Engineered neural tissue for peripheral nerve repair. Georgiou, Melanie; Bunting, Stephen C. J.; Davies, Heather A.; Loughlin, Alison J.; Golding, Jonathan P. and Phillips, James B Biomaterials, 34(30), pp. 7335–7343. Fabrication of an endoneurium using engineered neural tissue within a peripheral nerve repair conduit. Georgiou, Melanie; Golding, Jon; Loughlin, Jane and Phillips, James In: Tissue Engineering and Regenerative Medicine International Society - EU Meeting, 17-20 June 2013, Istanbul, Turkey. 2012A living replacement tissue for peripheral nerve that can enhance regeneration in vitro and in vivo.
Georgiou, Melanie; Bunting, Stephen; Golding, Jon; Loughlin, Jane and Phillips, James In: Tissue Engineering and Regenerative Medicine International Society - World Congress 2012, 5 - 8 September 2012, Vienna, Austria. A nerve repair conduit containing differentiated adipose-derived stem cells within engineered neural tissue can support and guide neuronal growth in vitro and in vivo. Georgiou, Melanie; Kingham, Paul; Bunting, Stephen; Golding, Jon; Loughlin, Jane and Phillips, James In: Tissue Engineering and Regenerative Medicine International Society - World Congress 2012, 5 - 8 September 2012, Vienna, Austria. Engineered neural tissue with aligned Schwann cells supports neuronal regeneration in vivo and can be assembled using differentiated adipose-derived stem cells. Georgiou, M.; Loughlin, J.; Golding, J. P.; Kingham, P. J. and Phillips, J. B. In: Annual meeting of the Tissue and Cell Engineering Society (TCES), 4-6 July 2012, Liverpool, UK. Engineered neural tissue with columns of aligned Schwann cell-like cells from differentiated adipose-derived stem cells can support and guide neuronal growth in vitro. Georgiou, Melanie; Kingham, Paul; Golding, Jon; Loughlin, Jane and Phillips, James In: 3rd International Conference on Stem Cell Engineering "Designing Cellular Therapies", 29 April - 02 May 2012, Seattle, US. 2011 Aligned Schwann cells within 3D tissue-like gels provide guidance to regenerating neuritis.
Georgiou, M.; East, E.; Loughlin, J.; Golding, J. and Phillips, J. In: 10th European Meeting on Glial Cells in Health and Disease, 13-17 September 2011, Prague, Czech Republic. Aligned cellular and acellular collagen guidance substrates for peripheral nerve repair. Georgiou, Melanie; Loughlin, Jane; Golding, Jon and Phillips, James In: Tissue and Cell Engineering Society, 19 - 21 July 2011, Leeds. 3d micro-structured collagen conduits for nerve repair. Karamsadkar, S.; Alekseeva, T.; Bunting, S.; Stomati, K.; Cheema, U.; Georgiou, M.; Phillips, J.; Brown, R. A. and Priestley, J. V In: Tissue Engineering & Regenerative Medicine International Society, 7-10 June 2011, Granada, Spain. A tissue engineered collagen conduit containing columns of aligned Schwann cells supports neuronal regeneration in vitro. Georgiou, M.; East, E.; Loughlin, A. J.; Golding, J. P. and Phillips, J. B. In: 2011 PNS Biennial Meeting of the Peripheral Nerve Society, 25-29 June 2011, Potomac, Maryland, US. 2010Schwann cells in collagen gels survive plastic compression and maintain their alignment: development of a cellular biomaterial for peripheral nerve repair.
Georgiou, M.; East, E.; Loughlin, J.; Golding, J.P. and Phillips, J.B. In: Tissue and Cell Engineering Society, 28-30th July, Manchester, U.K.. Plastic compression of aligned cellular collagen gels for nervous system repair. East, E.; Georgiou, M.; Loughlin, A.J.; Golding, J.P. and Phillips, J.B. In: Tissue Engineering and Regenerative Medicine International Society - EU Meeting, 13-17th June, Galway, Ireland Invited Talks
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